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The Miami Open presented by Itau will be without two Top 5 players when the tournament begins Wednesday.

No. 2 Rafael Nadal (right knee) and No. 5 Juan Martin del Potro (right knee) will miss the month’s second ATP Masters 1000 tournament. Del Potro also missed the BNP Paribas Open, where he won the 2018 title for his first Masters 1000 (d. Federer).

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The Argentine fractured his right patella at the Rolex Shanghai Masters last October and is still rehabbing the injury.

Nadal reached the semi-finals in Indian Wells but had to withdraw from his semi-final against Roger Federer because of pain in his right knee.

The Spaniard expects to return at Rolex Monte-Carlo Masters, the season’s first clay-court ATP Masters 1000 tournament. Nadal has won the tournament 11 times.